Dr. Keith Baar is a professor on the College of California, Davis, within the Division of Physiology and Membrane Biology.
Throughout his PhD research, his analysis revealed that mechanical pressure on muscle fibers prompts the mammalian goal of rapamycin (mTOR) signaling pathway, an important regulator of muscular hypertrophy.
Subsequently, he studied the molecular dynamics of skeletal muscle adaptation to endurance coaching below the steering of Dr. John Holloszy, a legend within the subject of train physiology, thought of the daddy of contemporary train biochemistry.
Constructing on all of this expertise, he carried out analysis into tendon well being and the potential for engineering ligaments, which might have implications for therapy and restoration from accidents.
Dr. Baar now runs the Purposeful Molecular Biology Lab at UC Davis. His lab’s work ranges from finding out molecular adjustments in our cells to conducting research to impact real-world enhancements in individuals’s well being, longevity, and high quality of life.
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Dr. Keith Baar, UC Davis — Easy Workouts That Can Restore Tendons (Tennis Elbow, and so forth.), Collagen Reality vs. Fiction, Isometrics vs. Eccentrics, JAK Inhibitors, Progress Hormone vs. IGF-1, The Anti-RICE Protocol, and Easy methods to Use Load as an Anti-Inflammatory
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SELECTED LINKS FROM THE EPISODE
- Join with Dr. Keith Baar:
The transcript of this episode could be discovered right here. Transcripts of all episodes could be discovered right here.
Physiology & Biology
Energy Physiology
Molecular Biology
Train Physiology
Harm & Restoration
Coaching & Rehabilitation Strategies
Substances & Interventions
Dietary supplements
Prescription drugs
Orthobiologics (Critiqued)
Diets
Establishments & Locations
Films
Analysis
Related Assets
SHOW NOTES
- [00:07:12] How I found Keith’s work by way of a tweet about tennis elbow and mountaineering.
- [00:07:54] Emil Abrahamsson’s hangboard coaching protocol.
- [00:09:20] The basic rules of energy coaching and connective tissue adaptation.
- [00:10:36] mTOR advanced 1 and its position in muscle development.
- [00:12:06] Engineered ligaments and the invention of minimal efficient doses for tendon adaptation.
- [00:13:50] The refractory interval between optimum tendon loading periods.
- [00:16:42] Rapamycin’s results on muscle hypertrophy.
- [00:18:49] Protocols for tennis elbow rehabilitation.
- [00:20:28] Why isometrics work higher than eccentrics for tendon therapeutic.
- [00:22:14] Stress shielding and the way load distribution impacts tendon therapeutic.
- [00:29:07] The misperception about eccentric loading for tendon accidents and why velocity issues.
- [00:29:58] Perfect period for isometric holds (10-30 seconds) based mostly on damage standing.
- [00:33:50] My elbow points and present rehab method.
- [00:36:02] Overcoming vs. yielding isometrics and optimum loading methods.
- [00:47:11] Dr. Barr’s motion prescription for my tennis elbow.
- [00:52:18] Loading timing post-surgery and RICE protocol criticism.
- [00:56:58] Achilles tendon rehabilitation after surgical procedure.
- [01:00:18] Critique of orthopedic suturing methods and advice for resorbable sutures.
- [01:04:02] A number of place isometrics for tennis elbow rehabilitation.
- [01:07:26] Collagen synthesis, supplementation, and vitamin C timing.
- [01:12:59] Critique of BPC-157 and different injectable peptides for tendon therapeutic.
- [01:18:19] Analysis of orthobiologics’ (PRP, prolotherapy, stem cells) effectiveness.
- [01:21:37] JAK-STAT inhibitor medicine and their results on tendon development.
- [01:25:35] Medicine that improve threat of tendon ruptures (fluoroquinolones, AT-1 receptor medicine).
- [01:29:33] How estrogen impacts tendon stiffness and damage threat in ladies.
- [01:32:48] Testosterone’s reverse results on tendon in comparison with estrogen.
- [01:35:31] Protein consumption suggestions and timing.
- [01:40:11] Ketogenic weight loss program results on mitochondrial biogenesis and longevity.
- [01:41:57] Comparability of ketogenic weight loss program, low protein weight loss program, and rapamycin for longevity.
- [01:47:19] Irritation’s position in adaptation and when to cut back it.
- [01:51:17] Timing of ice baths relative to coaching for optimum restoration.
- [01:52:33] Parting ideas.
MORE DR. KEITH BAAR QUOTES FROM THE INTERVIEW
“The primary price to the US medical system is definitely musculoskeletal sprains, strains, and tears—the again and the neck in addition to the remainder of the physique. It’s greater than diabetes and coronary heart illness mixed.”
— Dr. Keith Baar
“If passive flexibility have been actually vital for lowering tendon damage, then the ladies’s gymnasts who’ve probably the most passive flexibility wouldn’t be the NCAA sport with the very best charge of Achilles tendon rupture.”
— Dr. Keith Baar
“Harm associated to flexibility is a U-shaped curve. So our accidents are actually excessive once we’re very rigid. Once we get into that candy spot the place we now have good mobility, we will do the complete vary of movement, really the damage charge may be very low. If we grow to be hyper-mobile, we even have that damage charge go up as nicely.”
— Dr. Keith Baar
“We don’t use a ketogenic weight loss program if we wish to go quick, but when we’re coaching for all times, we see that it will increase longevity, that the ketones themselves are actually good for mind perform.”
— Dr. Keith Baar
“The primary recorded immobilizer for an ankle or a leg is from Egyptian hieroglyphs, the place they confirmed footage 4,500 years in the past. If I took you and also you stated you had most cancers, you wouldn’t desire a therapy that was developed 4,500 years in the past. You’d hope that one thing new had been developed within the final 4,500 years. That’s the place we’re for our orthopedic conditions.”
— Dr. Keith Baar
“The truth is that there are particularly sure athletes like climbers the place they’re doing every kind of heavy lifts, they’re doing every kind of heavy work, they’re doing every kind of actually dynamic strikes. And what occurs, what breaks down, is that they break down of their finger tendons and so they break down within the little pulleys inside the tendons.”
— Dr. Keith Baar
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