A multidisciplinary effort by Pilar Andrés and colleagues from varied facilities in Palma and in Madrid publishes proof that liver fibrosis could be a sound biomarker of dementia and cognitive decline.
Reference :Pujol, A., Sanchis, P., Tamayo, M. I., Godoy, S., Calvó, P., Olmos, A., Andrés, P., Speranskaya, A., Espino, A., Estremera, A., Rigo, E., Amengual, G. J., Rodríguez, M., Ribes, J. L., Gomila, I., Grases, F., González-Freire, M., & Masmiquel, L. (2024). Metabolic-Related Fatty Liver Illness and Cognitive Efficiency in Sort 2 Diabetes: Basal Information from the Phytate, Neurodegeneration and Diabetes (PHYND) Research. Biomedicines, 12(9), 1993. https://doi.org/10.3390/BIOMEDICINES12091993
Summary: The impact of liver fibrosis on gentle cognitive impairment (MCI) and dementia danger in kind 2 diabetes mellitus (T2DM) sufferers is unclear. Subsequently, we carried out a potential cross-sectional examine on 219 sufferers with T2DM and older than 60 years to guage the affiliation between liver fibrosis, liver steatosis, and cognitive impairment. The Montreal Cognitive Evaluation (MoCA) was used to display for MCI or dementia. Liver fibrosis was estimated utilizing the non-invasive Fibrosis-4 (FIB-4) rating, and liver steatosis was assessed with the hepatic steatosis index. The imply age was 71 ± 6 years, 47% have been girls and in keeping with MoCA cut-off values, 53.88% had MCI and 16.43% had dementia. A average or excessive danger of superior fibrosis was considerably increased in sufferers with MCI or dementia in comparison with these with regular cognition (p < 0.001). After adjusting for confounders, a FIB-4 rating larger than 1.54 was related to MCI or dementia (p = 0.039). Multivariate evaluation recognized age over 70.5 years, antiplatelet treatment use, and a FIB-4 rating above 1.54 as essentially the most related danger components. Liver fibrosis, however not liver steatosis, is related to MCI or dementia in older T2DM sufferers, suggesting that FIB-4 rating could be a easy biomarker for the detection of cognitive impairment.
